By Herbert F. Bender, Philipp Eisenbarth
This practice-oriented advisor covers the dealing with and use of damaging chemical substances on the office, together with labelling and garage, transportation, occupational safeguard and correct registration with the ecu gurus. present ecu Union laws and directives are mentioned in the course of the textual content, making this a worthy reference for corporations and associations either inside and out of the european universal marketplace.
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Extra resources for Hazardous Chemicals: Control and Regulation in the European Market
The embryo-damaging effect of alcohol (ethanol) has been well investigated and published in many epidemiological studies. Especially babies from alcoholic women show severe developmental defects. The documented effects are anatomical deformations and especially mental and cognitive disorders. There is no doubt that for developmental effects a no effect level exists. In the case of ethanol at the maximum allowed airborne workplace concentration, no developmental effects can occur. The necessary amount can only be incorporated orally.
Eye respiratory tract, or skin For investigations of dermal irritative properties, various test models are available. The classical OECD guideline is to apply the substance to the freshly shaved skin of a rabbit. This very sensitive skin should represent the behavior of highly sensitive people. In contrast to the testing of a corrosive reaction, which may only be investigated on the skin, an irritant reaction has to be tested additionally at the eyes. Animal test methods are not available for measuring an irritant effect on the respiratory tract.
3 Important industrial toxic compounds. 4 Very toxic and toxic constituents of plants. 2 21 25 37 65 a) [mg/kg] body weight, oral, rat, b) alkaloid, c) triterpene, d) Methyl-8-oxy-naphthoquinone. 3 are also classified as toxic. To distinguish them from the lethal effects, they are classified with the R-phrase R 39/. In order to distinguish them from very toxic substances, the R-phrases for toxic have to follow the R 39, as can be seen in the following example: R 39/24: Toxic: danger of very serious irreversible effects in contact with skin.