By Frank J. Dixon (Ed.)
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Extra info for Advances in Immunology, Vol. 42
As discussed in greater detail in Section I11 (Table I), other experiments demonstrated that the high frequency of sIg- T15’ B cells is apparently the result of a high frequency of recurrence of clones of this clonotype from within the generative cell pool as opposed to the generation of relatively large clones of cells bearing this specificity. This being the case, it would seem that the expression of predominant clonotypes is not only a reflection of B cell generative processes as opposed to environmental up-regulation, but the expression of predominant clonotypes is also the result of the frequent recurrence of certain V region segment combinations from within the generative cell pool.
D. ENVIRONMENTAL DOWN-REGULATION IN CLONOTYPE REPERTOIREEXPRESSION In contrast to the lack of evidence for environmental participation in either repertoire diversification or the up-regulation of the frequency of B cells of predominant clonotypes, there are now several examples wherein the frequency of mature splenic B cells of a given specificity or clonotype subset is significantly lower than anticipated from the normalized frequency of cells of the same specificity or clonotype subset present in the sIg- bone marrow precursor cell pool.
The final evidence that NP and NIP stimulated essentially the same population of h-bearing B cells was obtained by studies in which the frequency of responsive cells was assessed using either NP-Hy or NIP-Hy alone, or the two antigens in concert. In this situation, as seen in Table IV, the frequency of B cells stimulated by both antigens together was the same as the frequency stimulated by either antigen alone. , 1973), and even for responses of K-bearing B cells to NP and NIP (Riley and Klinman, 1986) the addition of two antigens yields additivity of responses, the complete overlap of the h-responsive B cells to NP and NIP in Igh” mice is a strong indication that these two haptenic determinants stimulate the same population of B cells.